Molecular mechanisms of epigenetic inheritance: Possible evolutionary implications
نویسندگان
چکیده
منابع مشابه
The evolutionary implications of epigenetic inheritance.
The Modern Evolutionary Synthesis (MS) forged in the mid-twentieth century was built on a notion of heredity that excluded soft inheritance, the inheritance of the effects of developmental modifications. However, the discovery of molecular mechanisms that generate random and developmentally induced epigenetic variations is leading to a broadening of the notion of biological heredity that has co...
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The mechanisms by which stable gene expression patterns are inherited during cell division are not well understood. Chromatin is subject to a number of covalent modifications and it is generally believed that the transfer of these modifications between cell generations plays a critical role in inheritance, though how this occurs is a matter of debate. In one proposed model, replication of chrom...
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Enhancer-blocking insulators are DNA elements that disrupt the communication between a regulatory sequence, such as an enhancer or a silencer, and a promoter. Insulators participate in both transcriptional regulation and global nuclear organization, two features of chromatin that are thought to be maintained from one generation to the next through epigenetic mechanisms. Furthermore, there are m...
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ژورنال
عنوان ژورنال: Seminars in Cell & Developmental Biology
سال: 2020
ISSN: 1084-9521
DOI: 10.1016/j.semcdb.2019.06.005